What causes are known to lead to an apparently negative, wrong result with pregnancy test?

Wrong negative results may be due to different causes, too:

  • Running of the pregnancy test at too low HCG concentrations, in case of a premature measurement, or if ovulation occurs clearly towards the end of the period, or if a strong attenuation is caused by increased passing of water.
  • In the event of a mutated HCG detection. Only very few women show alterations in the binding positions of the HCG-Molecule, avoiding interaction with the specific antibody. In such cases a different test based on detection with a different antibody may of course have different outcome. This phenomenon is known in modern Medical Diagnostics as a consequence of the unique individual genetic and biological skills. Therefore no single immunological test is exempted from failure under these quite rare circumstances.